HIPPOPOTO­MONSTRO­SESQUIPED­AL­IAN

HIPPOPOTO­MONSTRO­SESQUIPED­AL­IAN = pertaining to a very long word.
From Mrs. Byrne's Dictionary of Unusual, Obscure and Preposterous Words.

FLOCCI­NAUCINI­HILIPIL­IFICATION = an estimation of something as worthless.
This is the longest word in the first edition of the Oxford English Dictionary. Interestingly the most common letter in English, E, does not appear in this word at all, whilst I occurs a total of nine times. The word dates back to 1741. The 1992 Guinness Book of World Records calls flocci­nauci­nihili­pilification the longest real word in the Oxford English Dictionary, and refers to pneumono­ultra­micro­scopic­silico­volcano­koniosis as the longest made-up one.

PNEUMONO­ULTRA­MICRO­SCOPIC­SILICO­VOLCANO­CONIOSIS (also spelled PNEUMONO­ULTRA­MICRO­SCOPIC­SILICO­VOLCANO­KONIOSIS) = a lung disease caused by breathing in particles of siliceous volcanic dust.
This is the longest word in any English dictionary. However, it was coined by Everett Smith, the President of The National Puzzlers' League, in 1935 purely for the purpose of inventing a new "longest word". The Oxford English Dictionary described the word as factitious. Nevertheless it also appears in the Webster's, Random House, and Chambers dictionaries.

Two chemical terms (3,641 and 1,913 letters long) have appeared in the Guinness Book of World Records. They were withdrawn because they have never been used by chemists, and there is no theoretical limit to the length of possible legitimate chemical terms. A DNA molecule could have a name of over 1,000,000,000 letters if it was written out in full.

(1,185) ACETYL­SERYL­TYROSYL­SERYL­ISO­LEUCYL­THREONYL­SERYL­PROLYL­SERYL­GLUTAMINYL­PHENYL­ALANYL­VALYL­PHENYL­ALANYL­LEUCYL­SERYL­SERYL­VALYL­TRYPTOPHYL­ALANYL­ASPARTYL­PROLYL­ISOLEUCYL­GLUTAMYL­LEUCYL­LEUCYL­ASPARAGINYL­VALYL­CYSTEINYL­THREONYL­SERYL­SERYL­LEUCYL­GLYCYL­ASPARAGINYL­GLUTAMINYL­PHENYL­ALANYL­GLUTAMINYL­THREONYL­GLUTAMINYL­GLUTAMINYL­ALANYL­ARGINYL­THREONYL­THREONYL­GLUTAMINYL­VALYL­GLUTAMINYL­GLUTAMINYL­PHENYL­ALANYL­SERYL­GLUTAMINYL­VALYL­TRYPTOPHYL­LYSYL­PROLYL­PHENYL­ALANYL­PROLYL­GLUTAMINYL­SERYL­THREONYL­VALYL­ARGINYL­PHENYL­ALANYL­PROLYL­GLYCYL­ASPARTYL­VALYL­TYROSYL­LYSYL­VALYL­TYROSYL­ARGINYL­TYROSYL­ASPARAGINYL­ALANYL­VALYL­LEUCYL­ASPARTYL­PROLYL­LEUCYL­ISOLEUCYL­THREONYL­ALANYL­LEUCYL­LEUCYL­GLYCYL­THREONYL­PHENYL­ALANYL­ASPARTYL­THREONYL­ARGINYL­ASPARAGINYL­ARGINYL­ISOLEUCYL­ISOLEUCYL­GLUTAMYL­VALYL­GLUTAMYL­ASPARAGINYL­GLUTAMINYL­GLUTAMINYL­SERYL­PROLYL­THREONYL­THREONYL­ALANYL­GLUTAMYL­THREONYL­LEUCYL­ASPARTYL­ALANYL­THREONYL­ARGINYL­ARGINYL­VALYL­ASPARTYL­ASPARTYL­ALANYL­THREONYL­VALYL­ALANYL­ISOLEUCYL­ARGINYL­SERYL­ALANYL­ASPARAGINYL­ISOLEUCYL­ASPARAGINYL­LEUCYL­VALYL­ASPARAGINYL­GLUTAMYL­LEUCYL­VALYL­ARGINYL­GLYCYL­THREONYL­GLYCYL­LEUCYL­TYROSYL­ASPARAGINYL­GLUTAMINYL­ASPARAGINYL­THREONYL­PHENYL­ALANYL­GLUTAMYL­SERYL­METHIONYL­SERYL­GLYCYL­LEUCYL­VALYL­TRYPTOPHYL­THREONYL­SERYL­ALANYL­PROLYL­ALANYL­SERINE = Tobacco Mosaic Virus, Dahlemense Strain.  This word has appeared in the American Chemical Society's Chemical Abstracts and is thus considered by some to be the longest real word.

MORE BIG WORDS  and even MORE